AGREEMENT WITH APPLUS COMPANY
Disproquima is pleased to inform that agreement has been reached with Company APPLUS for sales rights of active ingredient called ECTOIN on worldwide and exclusive basis.
Applus+ Laboratories collaborates with the chemical, pharmaceutical, and biotechnological industries offer- ing integral industrialization and R&D services. We offer solutions focused on lowering time, costs, and risks in the production of all types of chemical processes.
We have a highly qualified staff, and flexible fully equipped facilities to carry out a large variety of projects. From our laboratories and pilot plant, we provide you with technological solutions throughout your products' value chain, covering the design, manufacture, and validation stages. For the pharmaceutical and related industries, we work under the strictest quality standards. Our pilot plant operates according to GMP and in compliance with the ICH-Q7 standards.
Applus has developed an innovation new biotechnological and peptide engineering process for production of ECTOIN. Ectoin® is a derivate of an amino acid found in extremophilic microorganisms. It protects them from extreme variations in temperatures from 60°C during noon to 0°C during the night and a low humidity of only 5%. Such conditions can be found in Wadi El Natrun (Natron Valley), Egypt. There, in a salt lake, Ectoin® was found for the first time. Each life-form that is not protected by Ectoin® would die under these conditions in a very short time. Ectoin® gives extremophiles the capability to survive in this environment.
Ectoin® has e.g. cell-protective properties that can be used in Medical Devices and Life Science as well as in cosmetics.
Some other properties of Ectoin® and their benefits for the respective applications are listed below:
Cell membranes are stabilized by Ectoin® and protected from the entry of e.g. allergens. This property is used in the Ectoin® Allergy products for the treatment of allergic rhinitis and conjunctivitis by reducing symptoms as for example redness, itching or burning.
Ectoin® has inflammation-reducing properties. Used in a cream, Ectoin® can prolong the flare-free phase of atopic dermatitis. Ectoin® in nose or throat sprays reduces the symptoms of the disease.
In eye drops and nasal sprays Ectoin® cares for a moist milieu of the epithelia. Ectoin® forms an Ectoin® Hydro Compex with the water outside of cells and keeps them humid.